The journal Biochimica et Biophysica Acta – Reviews on Cancer has recently published a paper entitled The impact of HPV infection on human glycogen and lipid metabolism – a review, written by Dr Katarzyna Sitarz, Dr Krzysztof Czamara, Dr hab. Sława Szostek and Dr hab. Agnieszka Kaczor, Prof. UJ.
‘Human papilloma virus (HPV) is a number one cause of cervical carcinoma with 99% of the cervical cancer patients being HPV positive. This tight link between HPV and cancer raises the question if and how HPV impact cells to reprogram their metabolism? Focusing on early phase proteins E1, E2, E5, E6 and E7 we demonstrate that HPV activates plethora of metabolic pathways and directly influences enzymes of the glycolysis pathway to promote the Warburg effect by increasing glucose uptake, activating glycolysis and pentose phosphate pathway, increasing the level of lactate dehydrogenase A synthesis and inhibiting β-oxidation. Our considerations lead to conclusion that HPV is substantially involved in metabolic cell reprogramming toward neoplastic phenotype and its metabolic activity is the fundamental reason of its oncogenicity’, reads the paper’s abstract.
